ChemicalBook CAS DataBase List 2,4-DIBROMOANISOLE

2,4-DIBROMOANISOLE synthesis

15synthesis methods

Product Name:2,4-DIBROMOANISOLE
CAS Number:21702-84-1
Molecular formula:C7H6Br2O
Molecular Weight:265.93

74-88-4
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21702-84-1
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$8.00/5g

Yield: 98.8%

Reaction Conditions:

Stage #1:2,4-dibromophenol with potassium carbonate in acetonitrile for 0.166667 h;
Stage #2:methyl iodide in acetonitrile at 0 - 60; for 12 h;

Steps:

F.i
Preparation F 4-f3-bromopropoxy)isophthalonitrile(i) 2.4-Dibromo-l-methoxybenzeneK₂CO₃ (34.5 g, 0.243 mol) was added to a solution of 2,4-dinitrophenol (25 g, 0.009 mol) in acetonitrile (250 mL) and stirred for 10 minutes. The reaction mixture was cooled to O⁰C, methyl iodide (15 mL, 0.240 mol) was added and the reaction mixture was stirred at 6O⁰C for 12 h under a nitrogen atmosphere. The reaction mixture was cooled to RT and filtered through a Celite bed. The filtrate was concentrated under reduced pressure to afford 2,4-dibromo-l- EPO methoxybenzene (26 g, 98.8%) as brown solid product. This was employed directly in the next step without further purification.

References:

ASTRAZENECA AB WO2006/135316, 2006, A1 Location in patent:Page/Page column 61-62