2,4-dichloro-6-(methylsulfanyl)pyrimidine synthesis
- Product Name:2,4-dichloro-6-(methylsulfanyl)pyrimidine
- CAS Number:1137576-60-3
- Molecular formula:C5H4Cl2N2S
- Molecular Weight:195.0697
49844-93-1
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Yield:1137576-60-3 72%
Reaction Conditions:
Stage #1: 2-chloro-4-(methylsulfanyl)pyrimidinewith 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex in tetrahydrofuran at 25;Inert atmosphere;
Stage #2: with 1,1,2-Trichloro-1,2,2-trifluoroethane in tetrahydrofuran at 25;Inert atmosphere;chemoselective reaction;
References:
Mosrin, Marc;Knochel, Paul [Chemistry - A European Journal,2009,vol. 15,# 6,p. 1468 - 1477] Location in patent:experimental part
