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Sodium thiomethoxide

CAS No.
5188-07-8
Chemical Name:
Sodium thiomethoxide
Synonyms
SODIUM METHANETHIOLATE;SODIUM METHYL MERCAPTIDE;METHYL MERCAPTAN SODIUM SALT;Sodium thiomethylate;Sodium methylthiolate;SODIUM METHYLMERCAPTAN;SODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM);Sodium me;thioformate;methanethiolate
CBNumber:
CB1476576
Molecular Formula:
CH3NaS
Molecular Weight:
70.09
MDL Number:
MFCD00174316
MOL File:
5188-07-8.mol
Last updated:2023-10-16 16:26:05

Sodium thiomethoxide Properties

Density 1.12[at 20℃]
vapor pressure 29hPa at 25℃
Flash point 27°C
storage temp. Flammables area
solubility soluble in Water
form Powder
color White to off-white
Water Solubility soluble
Merck 14,5956
BRN 3592983
InChI InChI=1S/CH4S.Na/c1-2;/h2H,1H3;/q;+1/p-1
InChIKey RMBAVIFYHOYIFM-UHFFFAOYSA-M
SMILES CS[Na]
LogP -2.33 at 20℃
CAS DataBase Reference 5188-07-8(CAS DataBase Reference)
FDA UNII LB29JWW8H7
EPA Substance Registry System Methanethiol, sodium salt (5188-07-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H226-H302-H314
Precautionary statements  P210-P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
Hazard Codes  C,F
Risk Statements  31-34-20/21/22-11-35-25-10
Safety Statements  26-36/37/39-45-16
RIDADR  UN 3263 8/PG 3
WGK Germany  3
1-34-10-13
HazardClass  4.3
PackingGroup  II
HS Code  29309090
NFPA 704
2
3 0

Sodium thiomethoxide price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 281018 Sodium thiomethoxide 95% 5188-07-8 1g $46.8 2024-03-01 Buy
Sigma-Aldrich 281018 Sodium thiomethoxide 95% 5188-07-8 5g $125 2024-03-01 Buy
TCI Chemical M0096 Methyl Mercaptan Sodium Salt (ca. 15% in Water) 5188-07-8 25g $38 2024-03-01 Buy
TCI Chemical M0096 Methyl Mercaptan Sodium Salt (ca. 15% in Water) 5188-07-8 500g $144 2024-03-01 Buy
Sigma-Aldrich 71742 Sodium methanethiolate technical, ≥90% (RT) 5188-07-8 5g $122 2024-03-01 Buy
Product number Packaging Price Buy
281018 1g $46.8 Buy
281018 5g $125 Buy
M0096 25g $38 Buy
M0096 500g $144 Buy
71742 5g $122 Buy

Sodium thiomethoxide Chemical Properties,Uses,Production

Description

Sodium methanethiolate or sodium thiomethoxide (CH3SNa, MeSNa) is the sodium conjugate base of methanethiol. This compound is commercially available as a white solid. Sodium Methanethiolate is used as a nucleophile in organic synthesis. This compound is also being used as a reagent to synthesize thiol-based suberoylanilide hydroxamic acid (SAHA) analogues, compounds that act as potent histone deacetylase inhibitors. It reacts with trifluoroacetic acid and water to produce the active form of sodium trifluoroacetate. The reaction mechanism is likely due to the formation of a bicyclic heterocycle that has been shown to be effective against a number of bacteria.

Chemical Properties

Very faint yellowish red clear liquid

Uses

Used to prepare a C-21 thioether of methyl 16-prednisolonecarboxylate by mesylate displacement.

Uses

Sodium thiomethoxide is a strong nucleophile used for the synthesis of methyl aryl sulfides from halo-arenes. Alkanethiolates are efficient reagents for SN2 dealkylation of esters and aryl ethers.

Reactivity Profile

Sodium thiomethoxide is a powerful nucleophile that can be used to prepare methylthioether and other organic compounds like ethyl bromide. Its hydrolysis in moist air produces methanethiol, which has a low odor threshold and a noxious fecal smell.

Purification Methods

Dissolve the salt (10g) in EtOH (10mL) and add Et2O (100mL). Cool and collect the precipitate, wash it with Et2O and dry it in a vacuum. It is a white powder which is very soluble in EtOH and H2O. [Billmann & Jensen Bull Soc Chim Fr 3 2318 1936, Beilstein 1 III 1212.]

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View Lastest Price from Sodium thiomethoxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Sodium thiomethoxide pictures 2023-09-23 Sodium thiomethoxide
5188-07-8
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Sodium thiomethoxide pictures 2022-10-18 Sodium thiomethoxide
5188-07-8
US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.
Sodium thiomethoxide  pictures 2022-02-25 Sodium thiomethoxide
5188-07-8
US $10.00 / ASSAYS 1ASSAYS 99% 500tons/month Shanxi Naipu Import and Export Co.,Ltd
SODIUM METHYL SULFIDE SODIUM THIOMETHOXIDE Sodium thiomethoxyde 1-Methanethiolsodiumsalt Sodium methanethiol Sodium thiomethoxide, pure, 95% Sodium thiomethoxide, Methanethiol sodium salt METHYL MERCAPTAN SODIUM SALT: 15% IN WATER Methyl Mercaptan Sodium Salt (ca. 15% in Water) Methanethiol sodium salt, Sodium methanethiolate, Sodium thiomethoxide Sodium thiomethoxide, 95%, pure Sodiothiomethane Sodium Methanethiolate Solution Sodium methanethiolate, 21% aq. soln. Sodium methanethiolate ,95% thioformate Methanethiol, sodiuMsalt (1:1) SodiuM Methanethiolate technical, >=90% (RT) SodiuM thioMethoxide 95% SodiuM thioMethoxide solution 21% in H2O SodiuM thioMethoxide, 20% in water Sodium Methanethiolate (~20% in Water) sodiuM Methylsulfanide SodiuM Methanethiolate, 15 wt.% solution in H2O Sodium thiomethoxide solution METHANETHIOL SODIUM SALT Sodium methanethiolate, 21% aqueous solution Sodium me Sodium methionine Sodium thiomethoxide, 15% in water methanethiolate SODIUM THIOMETHOXIDE, 21 VOL. % SOLN IN WATER, A PRODUCT OF ELF ATOCHEM (SMM) Sodium methylthiolate Sodium thiomethylate SODIUM METHYLMERCAPTAN METHYL MERCAPTAN SODIUM SALT SODIUM METHANETHIOLATE SODIUM METHYL MERCAPTIDE High purity Sodium thiomethoxide 5188-07-8 5188-7-8 1201-10-8 1201108 CH3NaS CH3SNa Building Blocks Na (Sodium) Compounds (excluding simple sodium salts) Typical Metal Compounds Classes of Metal Compounds Sulfur Compounds Thiol/Mercaptan Salts Organic Building Blocks Classes of Metal Compounds Na (Sodium) Compounds (excluding simple sodium salts) Typical Metal Compounds API Aliphatics Sulfur & Selenium Compounds