ChemicalBook CAS DataBase List 2,4-DICHLOROBIPHENYL

2,4-DICHLOROBIPHENYL synthesis

13synthesis methods

Product Name:2,4-DICHLOROBIPHENYL
CAS Number:33284-50-3
Molecular formula:C12H8Cl2
Molecular Weight:223.1

591-50-4 Synthesis

591-50-4
472 suppliers
$10.00/1g

68716-47-2
264 suppliers
$6.00/1g

33284-50-3
40 suppliers
$46.89/100mg

Yield: 80%

Reaction Conditions:

with potassium carbonate in methanol;water at 20; for 4 h;Suzuki-Miyaura coupling;

Steps:

4.4. General procedure for catalytic Suzuki-Miyaura reactions
Under air atmosphere, a round-bottomed flask was charged with the silica supported Pd catalyst 5 (21.2 mg, contain palladium 0.0025 mmol), K₂CO₃ (138 mg, 1.0 mmol), aryl halide (0.5 mmol), organoboron compound (0.6 mmol), and MeOH/H₂O (1:1, v/v, 2.0 mL). The reaction mixture was stirred at room temperature for 4 h, then the reaction solution was vacuum-filtered using a sintered-glass funnel and washed with Et₂O (5.0 mL), the combined organic layers were dried over Na₂SO₄, filtered, concentrated, and the residue was purified by flash chromatography on silica gel to obtain the desired cross-coupling product.

References:

Chen, Wei;Li, Pinhua;Wang, Lei [Tetrahedron,2011,vol. 67,# 2,p. 318 - 325] Location in patent:experimental part