[2-(4-Methoxyphenyl)-1,3-thiazol-5-yl]methanol synthesis
- Product Name:[2-(4-Methoxyphenyl)-1,3-thiazol-5-yl]methanol
- CAS Number:937668-37-6
- Molecular formula:C11H11NO2S
- Molecular Weight:221.28
914348-82-6
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937668-37-6
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Yield:937668-37-6 99%
Reaction Conditions:
with methanol;sodium tetrahydroborate in tetrahydrofuran at 0;
Steps:
22.b.2
(b)-2; The aldehyde compound (18.31 g, 83.51 mmol) obtained in Example 22(b)-1 was dissolved in a mixture of THF (150 mL) and methanol (100 mL), and sodium borohydride (3.16 g, 83.51 mmol) was then added to the solution at 0°C. The obtained mixture was stirred for 15 minutes. Thereafter, a 10% citric acid aqueous solution was added to the reaction solution, and the solvent was then distilled away, followed by extraction twice with ethyl acetate. The combined organic layer was washed with water and a saturated saline, and it was then dried over anhydrous sodium sulfate, followed by concentration, so as to obtain the title compound (18.2 g, yield: 99%) in the form of a white solid. 1H NMR (400 MHz, CDCl3): δ (ppm) = 7.87 (2H, d, J = 9.0 Hz), 7.65 (1H, s), 6.96 (2H, d, 9.0 Hz), 4.88 (2H, s), 3.86 (3H, s).
References:
EP2308838,2011,A1 Location in patent:Page/Page column 69
5720-07-0
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937668-37-6
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27088-84-2
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937668-37-6
10 suppliers
$394.00/500mg