ChemicalBook CAS DataBase List 2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE

2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE synthesis

5synthesis methods

Product Name:2-(4-METHYLPIPERAZINO)-3-PYRIDINAMINE
CAS Number:5028-17-1
Molecular formula:C10H16N4
Molecular Weight:192.26

5028-15-9 Synthesis

1-METHYL-4-(3-NITRO-2-PYRIDINYL)PIPERAZINE

5028-15-9
24 suppliers
$45.00/50mg

5028-17-1
47 suppliers
$118.00/1g

Yield:5028-17-1 81%

Reaction Conditions:

with ammonium formate;palladium 10% on activated carbon in methanol at 20; for 1 h;

Steps:

24

PREPARATION 24; 2-(4-Methylpiperazin-1-vQpyridin-3-ylamine;. PP26 (0.50 g, 2.25 mmol), ammonium formate (1.00 g, 15.85 mmol) and 10% Pd on carbon (0.050 g) in MeOH (20 mL) were stirred for 1 h at rt, then filtered (Celite) and concentrated. The residue was dissolved in EtOAc and washed with aq. K₂CO₃ and brine, dried (MgSO₄) and concentrated to yield 0.35 g (81 %) of PP24 as a purple oil that was used EPO without purification: NMR (CDCI₃) 7.77 (dd, J = 4.6, 1.7 Hz, 1 H), 6.90 (dd, J = 7.5, 1.7 Hz, 1 H), 6.79 (dd, J = 7.9, 5.0 Hz, 1 H), 3.71 (br s, 2H), 3.15 (br s, 4H), 2.57 (br s, 4H), 2.34 (s, 3H).

References:

WO2006/48727,2006,A1 Location in patent:Page/Page column 72-73