ChemicalBook CAS DataBase List 2-(4-Piperidinyloxy)Pyridine

2-(4-Piperidinyloxy)Pyridine synthesis

6synthesis methods

Product Name:2-(4-Piperidinyloxy)Pyridine
CAS Number:127806-46-6
Molecular formula:C10H14N2O
Molecular Weight:178.23

7379-35-3 Synthesis

7379-35-3
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$5.00/1g

109384-19-2 Synthesis

109384-19-2
469 suppliers
$5.00/1g

127806-46-6
36 suppliers
$183.00/1g

Yield:127806-46-6 100%

Reaction Conditions:

in tetrahydrofuran;dimethyl sulfoxide;

Steps:

21.A Preparation of N-hydroxy-2-[[4-(4-pyridinyloxy)-1-piperidinyl]sulfonyl]benzamide, Monohydrochloride

Part A: To a solution of N-BOC-4-hydroxypiperidine (3.00 g, 14.9 mmol) in dimethylsulfoxide (10 mL) are sequentially added 4-chloropyridine hydrochloride (2.35 g, 15.6 mmol) and potassium-t-butoxide (30.5 mL of a 1.0 M solution in tetrahydrofuran, 30.5 mmol). After 16 hr at ambient temperature, the reaction mixture is diluted with diethyl ether (100 mL) and washed with H₂O (3*) and brine, and then dried over sodium sulfate (Na₂SO₄). Concentration of the organic solution gives the desired 4-pyridyloxypiperidine (4.24 g, 100%) as a white solid. Analytical calculation for C₁₅H₂₂N₂O₃: C 64.73; H, 7.97; N, 10.06. Found: C, 64.48; H, 8.14; N, 9.82.

References:

US2003/171404,2003,A1

313490-35-6 Synthesis