![](/CAS/GIF/911466-96-1.gif)
2,4-Thiazoledicarboxylic acid,2-ethyl ester synthesis
- Product Name:2,4-Thiazoledicarboxylic acid,2-ethyl ester
- CAS Number:911466-96-1
- Molecular formula:C7H7NO4S
- Molecular Weight:201.2
![3-Bromopyruvic acid](/CAS/GIF/1113-59-3.gif)
1113-59-3
293 suppliers
$14.00/1g
![Ethyl thiooxamate](/CAS/GIF/16982-21-1.gif)
16982-21-1
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$6.00/1g
![2,4-Thiazoledicarboxylic acid,2-ethyl ester](/CAS/GIF/911466-96-1.gif)
911466-96-1
91 suppliers
$29.00/100mg
Yield: 73%
Reaction Conditions:
in 1,4-dioxane at 50; for 1.2 h;
Steps:
32
EXAMPLE 32Preparation of Intermediate Compound 32AA mixture of 3-bromopyruvic acid (16.37 g, 98.05 mmol) in anhydrous dioxane (90 ml_) was treated with ethyl thioamidooxalate (13.08 g, 98.22 mmol) for 1.2 h at 50 0C, and was then concentrated at 50 0C to yield a dry yellow solid. The crude product was dissolved in saturated sodium bicarbonate (150 mL) and water (150 mL). This solution was extracted with ethyl acetate (6 x 400 mL). The aqueous EPO
References:
SCHERING CORPORATION WO2008/54702, 2008, A1 Location in patent:Page/Page column 134-135
![Diethyl thiazole-2,4-dicarboxylate](/CAS/20180702/GIF/40235-67-4.gif)
40235-67-4
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![2,4-Thiazoledicarboxylic acid,2-ethyl ester](/CAS/GIF/911466-96-1.gif)
911466-96-1
91 suppliers
$29.00/100mg