ChemicalBook >> CAS DataBase List >>3-Bromopyruvic acid

3-Bromopyruvic acid

CAS No.
1113-59-3
Chemical Name:
3-Bromopyruvic acid
Synonyms
3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
CBNumber:
CB0380692
Molecular Formula:
C3H3BrO3
Molecular Weight:
166.96
MDL Number:
MFCD00002587
MOL File:
1113-59-3.mol
MSDS File:
SDS
Last updated:2024-12-18 13:37:16

3-Bromopyruvic acid Properties

Melting point 77-82 °C
Boiling point 223.4±23.0 °C(Predicted)
Density 1.7314 (rough estimate)
refractive index 1.4650 (estimate)
storage temp. 2-8°C
solubility water: soluble1g/10 mL, clear, colorless
form White crystalline solid
pka 1.84±0.54(Predicted)
color White to Almost white
Water Solubility Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
BRN 1746786
InChIKey PRRZDZJYSJLDBS-UHFFFAOYSA-N
CAS DataBase Reference 1113-59-3(CAS DataBase Reference)
FDA UNII 63JMV04GRK
EPA Substance Registry System Propanoic acid, 3-bromo-2-oxo- (1113-59-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  C
Risk Statements  34-20/21/22
Safety Statements  26-36/37/39-45-27
RIDADR  UN 3261 8/PG 2
WGK Germany  3
RTECS  UZ0840000
19-21
Hazard Note  Corrosive
TSCA  Yes
HazardClass  8
PackingGroup  II
HS Code  29183000
NFPA 704
0
3 0

3-Bromopyruvic acid price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 16490 Bromopyruvic acid ≥98.0% 1113-59-3 10g $112 2024-03-01 Buy
Sigma-Aldrich 16490 Bromopyruvic acid ≥98.0% 1113-59-3 50g $399 2024-03-01 Buy
TCI Chemical B1153 3-Bromopyruvic Acid >98.0%(T) 1113-59-3 5g $96 2024-03-01 Buy
TCI Chemical B1153 3-Bromopyruvic Acid >98.0%(T) 1113-59-3 25g $319 2024-03-01 Buy
Alfa Aesar L00720 Bromopyruvic acid, 97% 1113-59-3 2g $39.2 2024-03-01 Buy
Product number Packaging Price Buy
16490 10g $112 Buy
16490 50g $399 Buy
B1153 5g $96 Buy
B1153 25g $319 Buy
L00720 2g $39.2 Buy

3-Bromopyruvic acid Chemical Properties,Uses,Production

Chemical Properties

Off-white solid

Uses

Bromopyruvic acid is used as an affinity label for cysteine residues and a potential anti-cancer agent. It is involved in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids and substituted pyranones. It plays a vital role as a cross-linker between nucleic acids and proteins. It is used as an anticancer agent for lung tumors.

Uses

3-Bromopyruvic acid is an intermediate of the fungicide thiabendazole. It was also used in the synthesis of imidazo[1,2-a]pyridine-2-carboxylic acids.

Uses

Bromopyruvic Acid is a synthetic brominated derivative of pyruvic acid. Bromopyruvic Acid maybe a potential treatment for certain types of cancer as it has shown to be effective at eliminating aggress ive liver tumors.

Preparation

Synthesis method of 3-bromopyruvic acid: add a little concentrated sulfuric acid and solvent dichloromethane to pyruvic acid in a reaction flask, add bromine dropwise for about 3.5h and stir, a white precipitate is produced, then continue to stir for 1h, dilute with cyclohexane and petroleum ether, then cool the reaction mixture to get crystals, filter, wash with petroleum ether and dry to get the finished product of 3-bromopyruvic acid.

Definition

ChEBI: 3-bromopyruvic acid is a 2-oxo monocarboxylic acid that is pyruvic acid in which one of the methyl hydrogens is replaced by bromine. Synthetic brominated derivative and structural analog of pyruvic acid. Highly reactive alkylating agent. Anti-cancer drug It has a role as an alkylating agent and an antineoplastic agent. It is a 2-oxo monocarboxylic acid and an organobromine compound. It derives from a pyruvic acid. It is a conjugate acid of a 3-bromopyruvate.

General Description

Bromopyruvic acid is an affinity label for cysteine residues?. It acts as cross-linker between nucleic acids and proteins. Kinetics of inactivation of pancreatic ribonuclease A by bromopyruvic acid has been investigated.

storage

Store at -20°C

Purification Methods

Dry it by azeotropic distillation (with toluene), and then recrystallise it from dry CHCl3. Dry for 48hours at 20o (0.5 torr) over P2O5. Store it at 0o. [Labandiniere et al. J Org Chem 52 157 1987, Beilstein 3 III 1167.]

127-17-3
1113-59-3
Synthesis of 3-Bromopyruvic acid from Pyruvic acid
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View Lastest Price from 3-Bromopyruvic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-Bromopyruvic acid pictures 2024-11-19 3-Bromopyruvic acid
1113-59-3
US $41.00 / mg 95% 10g TargetMol Chemicals Inc.
3-Bromopyruvic acid pictures 2024-11-11 3-Bromopyruvic acid
1113-59-3
US $8.90-5.20 / kg 1kg 99% 10 tons Shandong Deshang Chemical Co., Ltd.
3-Bromopyruvic acid pictures 2024-10-29 3-Bromopyruvic acid
1113-59-3
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
3-Bromopyruvic acid ,97% 2-Oxo-3-bromopropionic acid Hexokinase II Inhibitor II, 3-BP 3-bromo-2-oxo-propanoicaci Bromopyruvic acid, 3-Bromo-2-oxopropionic acid NSC 11731 NSC 62343 Propanoic acid,3-broMo-2-oxo- BroMopyruvic acid >=97.0% (T) 3-bromo-2-keto-propionic acid bromo-pyruvicaci 3-BROMOPYRUVIC ACID CRYSTALLINE Bromopyruvicacidhydrate 3-BROMO-2-OXOPROPANOICACID(3-BROMOPYRUVICACID) 3-BROMOPYRUVIC ACID, 98+% 3-Bromopyruvic acid (Bromopyruvic acid Hexokinase II Inhibitor II, 3-BP - CAS 1113-59-3 - Calbiochem BROMOPYRUVIC ACID;3-BROMOPYRUVATE 4-Amino-5-(aminocarbonyl)imidazole H 3-Bromopyruvic acid (3-BP) Hexokinase II Inhibitor II 3-Brom-2-oxopropionsure 3-Bromopyruvic Acid > Bromopyruvic acid,98% 3-BROMO-2-OXOPROPANOIC ACID 2-Oxo-3-bromopropanoic acid bromopyruvate 3-bromopyruvate 3-BROMOPYRUVIC ACID BROMOPYRUVIC ACID 3-BROMO-2-OXOPROPIONIC ACID beta-bromopyruvicacid Bromopyruvic acid (3-bromopyruvic acid) 3-Bromopyruvic Acid, ≥ 98.0% 1113-59-3 C3H3O3Br BrCH2COCOOH C3H3BrO3 Building Blocks Carboxylic Acids Carbonyl Compounds C1 to C5 Organic Building Blocks Aliphatics Carboxylic Acids Organic acids Carboxylic Acids Piperidines