3-溴丙酮酸
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- CAS号:
- 1113-59-3
- 英文名:
- 3-Bromopyruvic acid
- 英文别名:
- 3-bromopyruvate;3-BROMOPYRUVIC ACID;3-BROMO-2-OXOPROPANOIC ACID;bromopyruvate;BROMOPYRUVIC ACID;2-Oxo-3-bromopropanoic acid;3-BROMO-2-OXOPROPIONIC ACID;beta-bromopyruvicacid;NSC 62343;NSC 11731
- 中文名:
- 3-溴丙酮酸
- 中文别名:
- 溴丙酮酸;3-溴庚酸;3-溴丙酮酸;3-溴代丙酮酸;溴丙酮酸,97%;3-溴丙酮酸97%;3-溴-2-氧代丙酸;3-溴-2-氧代丙酸3-溴丙酮酸;PERFEMIKER]溴丙酮酸,95%;3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- CBNumber:
- CB0380692
- 分子式:
- C3H3BrO3
- 分子量:
- 166.96
- MOL File:
- 1113-59-3.mol
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3-溴丙酮酸化学性质
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熔点:
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77-82 °C
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沸点:
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223.4±23.0 °C(Predicted)
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密度:
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1.7314 (rough estimate)
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折射率:
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1.4650 (estimate)
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储存条件:
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2-8°C
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溶解度:
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water: soluble1g/10 mL, clear, colorless
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形态:
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White crystalline solid
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酸度系数(pKa):
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1.84±0.54(Predicted)
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颜色:
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White to Almost white
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水溶解性:
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Soluble in water, dimethyl sulfoxide, ethyl acetate and water.
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BRN:
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1746786
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InChIKey:
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PRRZDZJYSJLDBS-UHFFFAOYSA-N
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CAS 数据库:
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1113-59-3(CAS DataBase Reference)
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EPA化学物质信息:
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Propanoic acid, 3-bromo-2-oxo- (1113-59-3)
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3-溴丙酮酸性质、用途与生产工艺
3-Bromopyruvic acid 是己糖激酶 II (hexokinase II, HXK II) 抑制剂,是一种有效的针对肝癌细胞的抗肿瘤剂。
3-Bromopyruvate enhances TRAIL-induced apoptosis in breast cancer cells.
3-Bromopyruvate (Bromopyruvic acid), a hexokinase II inhibitor, can induce apoptosis in hepatocellular carcinoma cells by inducing endoplasmic reticulum (ER) stress.
3-Bromopyruvate inhibits ATP generation and upregulates the expression of DR5. 3-Bromopyruvate upregulates CHOP, GRP78 and the phosphorylation of AMPK and augments TRAIL-induced Bax and caspase-3 levels.
Cell Viability Assay
Cell Line:
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MCF-7 and MDA-MB-231 cells
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Concentration:
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40, 80, 160 or 320 µM
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Incubation Time:
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24 hours
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Result:
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3-Bromopyruvate (80 and 160 µmol/l) and TRAIL (400 ng/ml) significantly inhibited cell viability.
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3-Bromopyruvate (8 mg/kg; i.p.; every 4 days for 28 days) shows a synergistic antitumor effect in MCF-7 cell xenografts in nude mice.
Animal Model:
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Female nude mice (BALB/c; 4-5-weeks old and 18-20 g)
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Dosage:
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8 mg/kg
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Administration:
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I.p.; every 4 days for 28 days
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Result:
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Showed antitumor efficacy in tumor xenografts.
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化学性质
3-溴代丙酮酸是白色固体,m.p.64~67℃。不溶于水。
用途
3-溴代丙酮酸是杀菌剂噻菌灵的中间体。
用途
半胱氨酸残基的亲和标记;核酸和蛋白质之间的交联剂
生产方法
其制备方法是将丙酮酸中加入少许浓硫酸和溶剂二氯甲烷置于反应瓶中,滴加溴约需3.5h,并搅拌,有白色沉淀产生,再继续搅拌1h,用环己烷和石油醚稀释,然后冷却反应混合物得到结晶,过滤,用石油醚洗涤并干燥得到产品。
类别
有毒物质
毒性分级
高毒
急性毒性
腹腔-小鼠 LD50: 72 毫克/公斤
可燃性危险特性
热分解排出有毒溴化物蒸汽
储运特性
库房通风低温干燥; 与食品原料分开存放
灭火剂
泡沫、干粉、二氧化碳、雾状水
3-溴丙酮酸
上下游产品信息
上游原料
下游产品
更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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2024/11/08 | L00720 | 溴丙酮酸, 97% Bromopyruvic acid, 97% | 1113-59-3 | 2g | 348元 |
2024/11/08 | L00720 | 溴丙酮酸, 97% Bromopyruvic acid, 97% | 1113-59-3 | 10g | 975元 |
3-溴丙酮酸
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1113-59-3, 3-溴丙酮酸 相关搜索:
- Piperidines
- Carboxylic Acids
- Organic acids
- Carboxylic Acids
- Aliphatics
- 化学试剂
- 医药化工原料
- 抑制剂
- 高端化学
- 有机化学
- 有机化工
- 材料中间体及助剂
- 细胞生物学试剂
- 农药原料
- 苯并咪唑类杀菌剂
- 羰基化合物
- 有机酸
- 有机砌块
- 羧酸
- 通用试剂
- 杀菌剂中间体
- 农药中间体
- Organic Building Blocks
- C1 to C5
- Carbonyl Compounds
- Carboxylic Acids
- Building Blocks
- C3H3BrO3
- BrCH2COCOOH
- C3H3O3Br
- PERFEMIKER]溴丙酮酸,95%
- 优选]3-BROMOPYRUVIC ACID
- HEXOKINASE II(己糖激酶II)抑制剂(3-BROMOPYRUVIC ACID)
- 3-溴丙酮酸、3-溴庚酸、3-溴代丙酮酸
- 3-溴代丙酮酸
- 溴丙酮酸
- 3-溴丙酮酸97%
- 3-溴-2-氧代丙酸
- 3-溴庚酸
- 3-溴-2-氧代丙酸3-溴丙酮酸
- 3-溴丙酮酸
- 溴丙酮酸,97%
- 1113-59-3
- 3-Bromopyruvic Acid, ≥ 98.0%
- Bromopyruvic acid (3-bromopyruvic acid)
- beta-bromopyruvicacid
- 3-BROMO-2-OXOPROPIONIC ACID
- BROMOPYRUVIC ACID
- 3-BROMOPYRUVIC ACID
- 3-bromopyruvate
- bromopyruvate
- 2-Oxo-3-bromopropanoic acid
- 3-BROMO-2-OXOPROPANOIC ACID
- Bromopyruvic acid,98%
- 3-Bromopyruvic Acid >
- 3-Brom-2-oxopropionsure
- Hexokinase II Inhibitor II
- 3-Bromopyruvic acid (3-BP)