2,5-BIS(3-METHOXYPHENYL)-1,3,4-OXADIAZOLE synthesis
- Product Name:2,5-BIS(3-METHOXYPHENYL)-1,3,4-OXADIAZOLE
- CAS Number:19748-58-4
- Molecular formula:C16H14N2O3
- Molecular Weight:282.29
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Yield:-
Reaction Conditions:
with Burgess Reagent in tetrahydrofuran at 100; for 0.166667 h;Microwave;
Steps:
1.94
1.74 mmol of 3-methoxybenzoic acid-N-3-(methoxybenzoyl) hydrazide, 2.09 mmol of Burgess reagent are dissolved in 10 ml of THF and heated under microwave conditions (100 W, 100° C.) for 10 minutes. After cooling to room temperature, the reaction mixture is washed with water, dried over magnesium sulfate, and the THF is removed on a rotary evaporator; yield: quantitative, white solid; Rf: (hexane/ethyl acetate 8:2): 0.65; 1H NMR (CD3COCD3, 500 MHz): 7.75 (m, 2H, Harom), 7.69 (m, 2H, Harom), 7.52 (t, J=7.80 Hz, 2H, Harom), 7.20 (ddd, J=1.00 Hz and J=2.50 Hz and J=7.80 Hz, 2H, Harom), 3.93 (s, 3H, OMe); 13C NMR (CD3COCD3, 125 MHz): 165.25, 161.20, 131.35, 126.15, 119.90, 118.60, 112.65, 55.95; IR: 2920, 1515, 1254, 854 cm-1.
References:
US2011/46147,2011,A1 Location in patent:Page/Page column 29-30
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