3-(1,3,4-OXADIAZOL-2-YL)PHENOL synthesis

8synthesis methods

Product Name:3-(1,3,4-OXADIAZOL-2-YL)PHENOL
CAS Number:5378-29-0
Molecular formula:C8H6N2O2
Molecular Weight:162.15

5818-06-4
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$23.84/1g

149-73-5 Synthesis

149-73-5
521 suppliers
$12.00/5g

5378-29-0
27 suppliers
$45.00/50mg

Yield:5378-29-0 92%

Reaction Conditions:

for 24 h;Reflux;

Steps:

3 Synthesis of 2- (3-hydroxyphenyl) -1,3,4-oxadiazole

A mixture of methyl 3-hydroxybenzoate (6.85 g, 45.0 mmol), hydrazine hydrate (11.2 mL of 80% aqueous solution) and ethanol (60 mL) was heated under reflux for 48 hours and then cooled to room temperature. Washed with cold water and dried to give the target product 3-hydroxybenzohydrazide 4.34g, yield 63%. The resulting 3-hydroxybenzohydrazide (4.34 g, 28.5 mmol) was then mixed with trimethoxymethane (19.7 mL) and heated to reflux for 24 hours. After cooling and removal of excess trimethoxymethane under reduced pressure, the crude product was isolated and purified by silica gel column chromatography to give 4.24 g of the target product in a yield of 92%.

References:

CN107266505,2017,A Location in patent:Paragraph 0048; 0050

122-51-0 Synthesis