2,5-dimethoxy-4-methylbenzoic acid synthesis
- Product Name:2,5-dimethoxy-4-methylbenzoic acid
- CAS Number:32176-94-6
- Molecular formula:C10H12O4
- Molecular Weight:196.2
4925-88-6
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Yield:32176-94-6 71%
Reaction Conditions:
with potassium permanganate in water at 75; for 2 h;
Steps:
1.b
b) 2,5-Dimethoxy-4-methylbenzoic acid; 23.86 g of 2,5-dimethoxy-4-methylbenzaldehyde in solution in 500 ml of water are heated to 75° C. and 29.3 g of potassium permanganate in solution in 500 ml of water are introduced. The reaction mixture is left at 75° C. for 2 hours, after which the pH is adjusted to 10 with 10% sodium hydroxide solution and the insoluble matter is filtered off hot and washed three times with 80 ml of hot water. The filtrate is cooled and the precipitate formed is filtered off and dried under vacuum at 40° C. to give white crystals; m.p.=120° C.; yield=71% 1H NMR: 2.15 (s, 3H); 3.73 (s, 6H); 6.94 (s, 1H); 7.17 (s, 1H); 12.40 (s, 1H).
References:
US2004/19091,2004,A1 Location in patent:Page/Page column 6
75056-76-7
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51267-09-5
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24599-58-4
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32176-96-8
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