ChemicalBook CAS DataBase List 2,5-Dimethylphenylboronic acid

2,5-Dimethylphenylboronic acid synthesis

7synthesis methods

Product Name:2,5-Dimethylphenylboronic acid
CAS Number:85199-06-0
Molecular formula:C8H11BO2
Molecular Weight:149.98

121-43-7
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$13.00/25mL

553-94-6
203 suppliers
$10.00/5g

7732-18-5
463 suppliers
$12.69/100ml

85199-06-0
251 suppliers
$6.00/1g

Yield: 62%

Reaction Conditions:

Stage #1:4-bromo-m-xylene with n-butyllithium in tetrahydrofuran at -78; for 2 h;Inert atmosphere;
Stage #2:Trimethyl borate in tetrahydrofuran at -78;Inert atmosphere;
Stage #3:water with hydrogenchloride in tetrahydrofuran at 20; for 1 h;Inert atmosphere;

Steps:

1-(2) Synthesis of [Intermediate 1-b]
1L round bottom flask, 1-bromo-2,5-dimethylbenzene (25.0g, 0.135mol), into 200mlof tetrahydrofuran was cooled to -78 ° C under a nitrogen atmosphere.To the cooled solution was added dropwise a 1.6M n-butyllithium (101ml, 0.162mol).After 2 hours stirring at the same temperature was added dropwise trimethyl borate(18.2g, 0.176mol).Put the 1 normal hydrochloric acid and then stirred for 1 hour at room temperature thesolution was acidified.The mixture was concentrated under reduced pressure, and recrystallized with nhexaneto give the [intermediate 1-b].(12.5g, 62%)

References:

SFC Co., Ltd.;Cha, Sun Wook;Jung, Kyung Suk;Park, Suk Bae;Kim, Hee Dae;Lee, Yu Lim;Song, Joo Man;Hwang, Moon Chan KR2015/52989, 2015, A Location in patent:Paragraph 0326-0331

553-94-6
203 suppliers
$10.00/5g

11113-50-1 Synthesis