2-(6-broMopyridin-2-yl)propan-2-ol synthesis

Yield: 100%

Reaction Conditions:

in diethyl ether at 20; for 0.5 h;Inert atmosphere;

Steps:

1.1 Step 1: Preparation of 2- (6-bromopyridin-2-yl) propan-2-ol (Int-1-b)
Dissolve methyl 6-bromopicolinate (Int-1-a) (5 g, 23.1 mmol) in diethyl ether (100 mL),Methyl magnesium iodide (17 mL, 50.8 mmol) was added under a nitrogen atmosphere, and the mixture was stirred at room temperature for 0.5 hours.Water and 2N hydrochloric acid were added to the reaction solution, and extracted three times with ethyl acetate.The organic layers were combined and washed successively with a saturated aqueous sodium hydrogen carbonate solution and a saturated saline solution.It was dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated to obtain the title compound (5 g, yield: 100%) in this step.

References:

Sichuan Kelun Botai Bio-pharmaceutical Co., Ltd.;Liu Jinming;He Ting;Cai Jiaqiang;Chen Qiangqiang;Kang Xiwei;Wang Lichun;Wang Jingyi CN110467615, 2019, A Location in patent:Paragraph 0176-0180