![](/CAS/20150408/GIF/1319804-29-9.gif)
2,6-Dichloro-5-cyclopropylnicotinonitrile synthesis
- Product Name:2,6-Dichloro-5-cyclopropylnicotinonitrile
- CAS Number:1319804-29-9
- Molecular formula:C9H6Cl2N2
- Molecular Weight:213.06
![2,6-Dichloro-5-iodonicotinonitrile](/CAS/20180703/GIF/1353087-61-2.gif)
1353087-61-2
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![Cyclopropylboronic acid](/CAS/GIF/411235-57-9.gif)
411235-57-9
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$6.00/1g
![2,6-Dichloro-5-cyclopropylnicotinonitrile](/CAS/20150408/GIF/1319804-29-9.gif)
1319804-29-9
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Yield:1319804-29-9 70%
Reaction Conditions:
palladium diacetate;tricyclohexylphosphine in water;toluene;Reflux;Suzuki Coupling;
Steps:
9
[0539] A mixture of compound 2,6-dichloro-5-iodonicotinonitrile (10 g, 33.4 mmol), cyclopropylboronic acid (3.5 g, 40.1 mmol), K3PO4 (28 g, 133.6 mmol), Cy3P (1 g, 3.3 mmol) and Pd(OAc)2 (0.5 g, 2.2 mmol) in Toluene/H20 (300 mL/15 mL) was stirred under refluxing overnight. The mixture was poured into water and extracted with EtOAc. The separated organics was dried, concentrated and purified by column chromatography (Petroleum ether :EtO Ac = 10: 1) to give compound 2,6- dichloro-5-cyclopropylnicotinonitrile (5 g, 70%). 1H-NMR (400MHz, CDC13) δ (ppm) 7.43 (s, 1H), 2.08 (m, 1H), 1.18 (m, 2H), 0.69 (m, 2H)
References:
WO2011/94450,2011,A1 Location in patent:Page/Page column 158
![3-Pyridinecarboxamide, 1,2-dihydro-6-hydroxy-5-iodo-2-oxo-](/CAS/20210305/GIF/1319804-28-8.gif)
1319804-28-8
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![2,6-Dichloro-5-cyclopropylnicotinonitrile](/CAS/20150408/GIF/1319804-29-9.gif)
1319804-29-9
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![2 6-DIHYDROXYNICOTINAMIDE 95](/CAS/GIF/35441-11-3.gif)
35441-11-3
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$223.00/1g
![2,6-Dichloro-5-cyclopropylnicotinonitrile](/CAS/20150408/GIF/1319804-29-9.gif)
1319804-29-9
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