2,6-dichloro-N-methylaniline synthesis

5synthesis methods

Product Name:2,6-dichloro-N-methylaniline
CAS Number:56462-00-1
Molecular formula:C7H7Cl2N
Molecular Weight:176.04

608-31-1 Synthesis

608-31-1
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74-88-4
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Yield:56462-00-1 96%

Reaction Conditions:

Stage #1: 2,6-Dichloroanilinewith n-butyllithium in tetrahydrofuran;hexane at -78 - -40;
Stage #2: methyl iodide in tetrahydrofuran;hexane;Cooling;

References:

Zeevaart, Jacob G.;Wang, Ligong;Thakur, Vinay V.;Leung, Cheryl S.;Tirado-Rives, Julian;Bailey, Christopher M.;Domaoal, Robert A.;Anderson, Karen S.;Jorgensen, William L. [Journal of the American Chemical Society,2008,vol. 130,# 29,p. 9492 - 9499] Location in patent:supporting information; experimental part