2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE synthesis
- Product Name:2,6-DIFLUORO-4-METHOXYBENZYL BROMIDE
- CAS Number:94278-68-9
- Molecular formula:C8H7BrF2O
- Molecular Weight:237.04
79538-27-5
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$150.00/5G
94278-68-9
54 suppliers
$67.50/250mg
Yield:94278-68-9 66%
Reaction Conditions:
with phosphorus(V) oxybromide in tetrahydrofuran at 20; for 2 h;
Steps:
56.3 Step3:
Step3: To a cold stirring solution of (2,6-difluoro-4-methoxyphenyl)MeOH (0.5 g, 2.87 mmol, 1 eq) in THF (20 ml) was portion wise added ROB FontWeight="Bold" FontSize="10" (1.65 g, 5.74 mmol, 2 eq). The reaction mixture then stirred for 2 h at RT. The reaction mixture was quenched by saturated NaHCCb solution under cooling conditions. The organic layer was separated and aqueous layer was extracted by EtOAc (50 ml). The combined organic layer was washed by water (30 ml) and brine (30 ml). [71] The organic layer was dried over anhydrous Na2SC>4, concentrated under reduced pressure to get the crude material which was purified by silica gel (230-400 mesh silica gel; 10% EtO Ac/hexane; R value-0.5) to afford 2-(bromomethyl)-1,3-difluoro-5-methoxybenzene (0.45 g, 66%) as color less liquid.
References:
WO2019/170904,2019,A1 Location in patent:Page/Page column 69-73
79538-28-6
31 suppliers
$13.00/250mg
94278-68-9
54 suppliers
$67.50/250mg
84937-82-6
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$22.00/100mg
94278-68-9
54 suppliers
$67.50/250mg
256417-10-4
147 suppliers
$11.00/1g
94278-68-9
54 suppliers
$67.50/250mg