2,6-Difluoro-4-nitrophenol synthesis
- Product Name:2,6-Difluoro-4-nitrophenol
- CAS Number:658-07-1
- Molecular formula:C6H3F2NO3
- Molecular Weight:175.09
28177-48-2
300 suppliers
$15.00/5 g
141-78-6
607 suppliers
$20.50/250ml
658-07-1
109 suppliers
inquiry
Yield: 51%
Reaction Conditions:
with nitric acid in hexane;acetic acid
Steps:
R.103 2,6-Difluoro-4-nitrophenol
Reference Example 103 2,6-Difluoro-4-nitrophenol To a solution of 2,6-difluorophenol (2.00 g) in acetic acid (20 ml) was added dropwise 60% nitric acid (1.20 ml) in an ice bath and the mixture was stirred at room temperature for 1 hour. After pouring into iced water, the reaction mixture was extracted with ethyl acetate. The extract was washed with brine. The organic layer was dried over anhydrous magnesium sulfate, filtered and the filtrate concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=3/1→2/1 as an eluant to give the desired compound (1.37 g, yield 51%) as a pale yellow solid. 1H NMR (400 MHz, CDCl3) δ ppm: 7.95 (2H, m).
References:
Sankyo Company, Limited US6555556, 2003, B1
28177-48-2
300 suppliers
$15.00/5 g
658-07-1
109 suppliers
inquiry
66684-58-0
205 suppliers
$10.00/1g
658-07-1
109 suppliers
inquiry
5509-65-9
470 suppliers
$10.00/10g
658-07-1
109 suppliers
inquiry