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ChemicalBook CAS DataBase List 2-Acrylamide-2-methylpropanesulfonic acid
15214-89-8

2-Acrylamide-2-methylpropanesulfonic acid synthesis

2synthesis methods
2-Acrylamido-2-methylpropanesulfonic acid(AMPS) can be synthesized by one step and two steps. The one-step method is to react the raw materials acrylonitrile, isobutylene and oleum together. The two-step method is to sulfonate isobutylene in the presence of a reaction solvent to obtain a sulfonated intermediate, and then react with acrylonitrile in the presence of sulfuric acid. One-step method is more economical. Raw material consumption quota: isobutylene 300kg/t, acrylonitrile 290kg/t, oleum 560kg/t.
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Yield:15214-89-8 92.2%

Reaction Conditions:

with sulfur trioxide at 8 - 35;Temperature;

Steps:

2 1) Preparation of 2-acrylamido-2-methylpropanesulfonic acid

Acrylonitrile and sulfur trioxide were respectively fed from the metered dose at a flow rate of 225 g / h and 30 g / h into the agitator Glass containers were mixed, the glass container with outer jacket cooling method, control the temperature to keep at 8 ° C. With the mixing of acrylonitrile and sulfur trioxide, the mixture flows continuously into the primary reactor with agitator through the overflow port at the middle of the glass vessel. At the same time, the isobutene was vaporized and added to the primary reactor at a feed rate of 22.6 g / h, and the temperature in the primary reactor was controlled by a water bath at 35 ° C. The reaction solution flows into the secondary reactor through the middle overflow of the primary reactor. At the same time, the vaporized isobutylene and sulfur trioxide were fed to the secondary reactor at a feed rate of 17.4 g / h and 20 g / h, respectively, and the temperature in the reactor was controlled at 35 ° C with a water bath. The reaction liquid in the secondary reactor flows into the hydrolysis reactor through the central overflow port. Deionized water was added dropwise to the hydrolysis reactor at a rate of 15 g / h to produce a white slurry. The white slurry was flowed out of the middle of the hydrolysis reactor into the centrifuge for solid-liquid separation, and the solid was dried to give the 2-acrylamido-2-methylpropanesulfonic acid product as a white powder.The above white powdery 2-acrylamido-2-methylpropanesulfonic acid product was subjected to liquid chromatography analysis and the results showed that the purity of the product was 97.1% and the calculated yield was 92.2%

References:

CN104211622,2016,B Location in patent:Paragraph 0026-0028

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