2-AMINO-1-PYRROLINE HYDROCHLORIDE synthesis

Yield:-

Reaction Conditions:

with ammonium chloride in ethanol at 20; for 24 h;

Steps:

1.A

Step A: Preparation of 3,4-dihydro-2H-pyrrol-5-amine hydrochloride (1:1) To a stirred solution of 3,4-dihydro-5-methoxy-2H-pyrrole (5.00 g, 50.43 mmol) in ethanol (30 mL) was added ammonium chloride (2.68 g, 50.43 mmol). The reaction mixture was stirred at room temperature for 24 h. The organic layer was then concentrated under reduced pressure to afford the title product as a white solid (6.0 g), which was used without further purification in the next step.

References:

US2010/99561,2010,A1 Location in patent:Page/Page column 19