ChemicalBook CAS DataBase List 6-(Chloromethyl)uracil

6-(Chloromethyl)uracil synthesis

8synthesis methods

Product Name:6-(Chloromethyl)uracil
CAS Number:18592-13-7
Molecular formula:C5H5ClN2O2
Molecular Weight:160.56

22126-44-9 Synthesis

22126-44-9
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18592-13-7
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Yield:18592-13-7 90.8%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in dichloromethane for 2 h;Reflux;Reagent/catalyst;

Steps:

9.3
In a 250 mL three-necked flask,Compound 2 (11.5 g, 0.081 mol) was added,Then, 115 mL of dichloromethane was added successively,Thionyl chloride (17.6 mL, 0.24 mol) and a catalytic amount of N, N-dimethylformamide,Add the temperature to reflux and stir the reaction for 2 hours.Cooled to room temperature,Filter,Dichloromethane wash,dry,11.8 g of 6-chloromethyluracil was obtained in a yield of 90.8%.

References:

Shandong Chuangxin Pharmaceutical Research And Development Co., Ltd.;Jiang Hong;Lv Chuantao;Ma Chonglei;Lin Hongjie;Hao Lianfeng;Liu Yongyong;Lu Jingjing CN106831607, 2017, A Location in patent:Paragraph 0049

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