2-Amino-3-bromo-5-cyanopyridine synthesis

Yield: 95%

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 20;

Steps:

4.1 1) Synthesis of Compound 4b
A reaction was performed at room temperature while stirring 2.00 g (16.8 mmol, 1 equivalent) of Compound 4a and 1.2 equivalents of N-bromosuccinimide under an acetonitrile solvent. After the reaction was terminated, water was poured thereto. Extraction was performed by using chloroform, the extract was washed with Na₂S₂O₃ (aq), and then the moisture was removed over anhydrous magnesium sulfate. 3.16 g (yield 95%) of Compound 4b could be obtained by concentrating the residue through distillation under reduced pressure.

References:

LG CHEM, LTD.;LEE, Milim;SON, Seonkyoung;SONG, Cheol Jun;MOON, Sang Pil;LEE, Hoyong US2020/95265, 2020, A1 Location in patent:Paragraph 0140-0141