ChemicalBook CAS DataBase List 2-Amino-3-nitrobenzoic acid

2-Amino-3-nitrobenzoic acid synthesis

8synthesis methods

Product Name:2-Amino-3-nitrobenzoic acid
CAS Number:606-18-8
Molecular formula:C7H6N2O4
Molecular Weight:182.13

3970-35-2 Synthesis

3970-35-2
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$6.00/250mg

606-18-8
302 suppliers
$9.00/1g

Yield:606-18-8 80%

Reaction Conditions:

with ammonia in water at 120; for 7 h;Sealed vessel;

Steps:

12
[0322] 2-Chloro-3-nitrobenzoic acid (20.6 g, 0.24 mol) was dissolved in ammonium hydroxide solution (120 mL) and the reaction mixture stirred at 120° C. in a sealed vessel for 7 hours. The reaction mixture was diluted with water (250 mL) and acidified to pH 2 with hydrochloric acid. The precipitate formed was filtered off and dried in vacuo to yield the title product, 15.0 g (80%). [0323] 1HNMR (CD3OD, 400 MHz): 6.65(dd, 1H), 8.24(dd, 1H), 8.32(dd, 1H).

References:

Pfizer Inc US2005/20626, 2005, A1 Location in patent:Page 17

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