2-amino-4-(benzyloxy)phenol synthesis

6synthesis methods

Product Name:2-amino-4-(benzyloxy)phenol
CAS Number:102580-07-4
Molecular formula:C13H13NO2
Molecular Weight:215.25

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Yield:102580-07-4 95%

Reaction Conditions:

in acetatic acid;

Steps:

29 Production of 6-(5-benzyloxybenzoxazol-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide

Example 29 Production of 6-(5-benzyloxybenzoxazol-2-ylthio)-N-(2,6-diisopropylphenyl)hexanamide To a solution in acetatic acid (21 ml) of 4-benzyloxy-2-nitrophenol (1.67 g, 6.8 mmol) was added zinc (8.89 g, 136 mmol) under cooling in ice bath, with stirring at ambient temperature for 2 hours. Zinc was filtered off by using celite; the filtrate was adjusted to neutrality with sodium hydrogen carbonate, and extracted with ethyl acetate. The organic layer was sequentially washed with an aqueous sodium hydrogen carbonate solution, water and saturated sodium chloride solution and dried over anhydrous sodium sulfate, from which the solvents were distilled off to recover 4-benzyloxy-2-aminophenol (1.40 g at a yield of 95%) as a brown oil.

References:

US6362208,2002,B1