ChemicalBook CAS DataBase List 2-Amino-4-bromo-3-fluorobenzoic acid

2-Amino-4-bromo-3-fluorobenzoic acid synthesis

7synthesis methods

Product Name:2-Amino-4-bromo-3-fluorobenzoic acid
CAS Number:1416013-62-1
Molecular formula:C7H5BrFNO2
Molecular Weight:234.02

The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid.png

synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid.png

1336963-95-1
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$58.00/100mg

1416013-62-1
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$8.00/100mg

Yield:1416013-62-1 94%

Reaction Conditions:

with dihydrogen peroxide;sodium hydroxide at 0 - 20; for 16 h;

Steps:

1 2-Amino-4-bromo-3-fluorobenzoic acid

To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 ^oC, H₂O₂ (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na₂SO₃, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).

References:

WO2016/164675,2016,A1 Location in patent:Page/Page column 231-232

194804-91-6 Synthesis