ChemicalBook CAS DataBase List 2-amino-5-bromo-3-nitrobenzoic acid

2-amino-5-bromo-3-nitrobenzoic acid synthesis

5synthesis methods

Product Name:2-amino-5-bromo-3-nitrobenzoic acid
CAS Number:58580-07-7
Molecular formula:C7H5BrN2O4
Molecular Weight:261.03

49764-59-2
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58580-07-7
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Yield:58580-07-7 96%

Reaction Conditions:

with dihydrogen peroxide;sodium hydroxide in water at 0 - 20; for 4 h;

Steps:

2 Preparation 2: 2-amino-5-bromo-3-nitro-benzoic acid

To a stirred solution of 5-bromo-7-nitro-1H-indole-2,3-dione (5.5 g, 20.3 mmol) in an aq.solution of 2N NaOH (23.2 mL) was added a 50% solution of H202 in water (4.96 mL) slowly at 0°C. Then allowed to warm to room temperature and stirred for 4 h. The progress of the reaction was monitored by TLC and the reaction mixture was diluted with water and acidified with citric acid to pH-4. The yellow solid formed was filtered and dried under vacuum to get the title compound (5.0 g, 96.0%). ‘H NMR (400 MHz, DMSO-d6): ? 8.84 (bs, 2H), 8.59 (s, 1H), 8.37 (s, 1H).

References:

WO2018/154088,2018,A1 Location in patent:Paragraph 0144

606-18-8 Synthesis