2-Amino-5-bromo-3-phenylpyrazine synthesis

4synthesis methods

Product Name:2-Amino-5-bromo-3-phenylpyrazine
CAS Number:344940-70-1
Molecular formula:C10H8BrN3
Molecular Weight:250.09

24241-18-7 Synthesis

24241-18-7
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98-80-6 Synthesis

98-80-6
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344940-70-1
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Yield:344940-70-1 95%

Reaction Conditions:

with potassium phosphate;tetrakis(triphenylphosphine) palladium⁽⁰⁾ in ethanol;toluene;Inert atmosphere;

Steps:

171.1

[00183] A mixture of 3,5-dibromopyrazin-2-amine (214 mg, 0.83 mmol) and phenyl boronic acid (100 mg, 0.8 mmol) in toluene (8 mL) was degassed and backfilled with nitrogen 3 times. Pd(PPtLs)₄ (46 mg) was added followed by 2M K₃PO₄ (0.8 mL) and EtOH (1 mL). The mixture was heated at reflux for 18 h. The solution was cooled to room temperature, partitioned between EtOAc (25 mL) and water (5 mL). The layers were separated and the organic layer dried over Na₂SO₄, filtered and concentrated to an oil which was purified via silica gel chromatography (15% EtOAc/heptane) to afford the product (187 mg, 95% yield).

References:

WO2009/155389,2009,A1 Location in patent:Page/Page column 85-86

41270-67-1 Synthesis