2-Amino-5-chloropyrazine synthesis
- Product Name:2-Amino-5-chloropyrazine
- CAS Number:33332-29-5
- Molecular formula:C4H4ClN3
- Molecular Weight:129.55
5049-61-6
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33332-29-5
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$14.00/1g
Yield:33332-29-5 80%
Reaction Conditions:
with N-chloro-N-methoxy-4-methylbenzenesulfonamide in acetonitrile at 40; for 4 h;Reagent/catalyst;Temperature;
Steps:
Preparation of 2-amino-5-chloropyrazine (17)
Method B. To a suspension of 2-aminopyrazine (3 g, 31.6 mmol) in acetonitrile (50 mL) was added N-chloro-N-methoxy-4-methylbenzenesulfonamide (TSA, 8.2 g,34.7 mmol) in batches at room temperature. The reaction mixture was heated at 40 °C for 4 h. Subsequently, the solvent was evaporated in vacuum and the residue was partitioned between ethyl acetate (50 mL) and saturated aqueous Na2CO3solution (20 mL). The organic layer was dried over anhydrous Na2SO4,decolorized with activated charcoal (0.8 g), and concentrated. The crude product containing ~ 5% dichlorinated impurity judged by TLC was purified by chromatography on silica gel eluting with PE/EA (10:1-2:1) to give a light-yellow solid (3.3 g, yield 80%).
References:
Guo, Qi;Xu, Mingshuo;Guo, Shuang;Zhu, Fuqiang;Xie, Yuanchao;Shen, Jingshan [Chemical Papers,2019,vol. 73,# 5,p. 1043 - 1051]
5049-61-6
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6863-73-6
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33332-29-5
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$14.00/1g
873-42-7
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1458-03-3
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33332-29-5
249 suppliers
$14.00/1g
5049-61-6
430 suppliers
$8.00/10g
33332-29-5
249 suppliers
$14.00/1g
873-42-7
142 suppliers
$30.00/1g
6863-77-0
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6863-73-6
217 suppliers
$10.00/5g
33332-29-5
249 suppliers
$14.00/1g
33332-28-4
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$9.00/1g