2-AMINO-5-ETHYL-3-THIOPHENECARBONITRILE synthesis

Yield:635302-32-8 85%

Reaction Conditions:

with sulfur;choline chloride;urea;sodium hydroxide in water at 60;Green chemistry;Gewald Aminoheterocycles Synthesis;

Steps:

Typical procedure for the synthesis of 2-aminothiophene derivatives

General procedure: A mixture of 0.070 g 4-propylcyclohexanone (0.5 mmol),0.030 g malononitrile (0.5 mmol), 0.019 g sulfur powder(0.6 mmol), and 0.1 cm³ NaOH (4 mol dm-3 aqueoussolution) in 1 cm³ choline chloride/urea was stirred at 60°C for 2-3 h. After completion of the reaction, indicated by TLC monitoring, 5 cm³ water was added. The solid product was separated by filtration and if necessary the precipitate recrystallized from EtOH to afford the corresponding pure product

References:

Shaabani, Ahmad;Hooshmand, Seyyed Emad;Afaridoun, Hadi [Monatshefte fur Chemie,2017,vol. 148,# 4,p. 711 - 716]