ChemicalBook CAS DataBase List 2-Amino-6-fluoropyridine

2-Amino-6-fluoropyridine synthesis

3synthesis methods

Product Name:2-Amino-6-fluoropyridine
CAS Number:1597-32-6
Molecular formula:C5H5FN2
Molecular Weight:112.11

1513-65-1
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1597-32-6
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Yield:1597-32-6 94%

Reaction Conditions:

with ammonia in water at 105; for 15 h;

Steps:

13.A
Example 13: (4S)-Λ/-Methyl-Λ/-(f5-(4-methyl-1-piperazinvnimidazoϖ .2-aloyridin-2- vϖmethyl)-3,4-dihvdro-2H-pyranof3,2-b1pyridin-4-arnine EPO A) 6-Fluoro-2-pyridinamine: A solution of 2,6-difluoropyridine (50 g, 434 mmol) in ammonium hydroxide (200 mL, 28.0- 30.0%) was heated at 105⁰C in a steel bomb for 15 hours. The reaction was cooled in an ice bath and the precipitate filtered, rinsed with cold water, and dried to yield 6-fluoro-2- pyridinamine (45.8 g, 94% yield) as a white solid. ¹H-NMR (CDCI₃): δ 7.53 (m, 1 H)₁ 6.36 (dd, 1 H), 6.26 (dd, 1 H), 4.56 (s, 2H).

References:

SMITHKLINE BEECHAM CORPORATION WO2006/76131, 2006, A2 Location in patent:Page/Page column 39-40

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258343-71-4 Synthesis

Acetamide, N-(6-fluoro-2-pyridinyl)- (9CI)

258343-71-4
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1597-32-6
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References

1075-62-3
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$8.00/1g

1597-32-6
231 suppliers
$7.00/1g

References

2-Amino-6-fluoropyridine Related Search:

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