2-Amino-6-iodopurine synthesis
- Product Name:2-Amino-6-iodopurine
- CAS Number:19690-23-4
- Molecular formula:C5H4IN5
- Molecular Weight:261.02
10310-21-1
535 suppliers
$10.00/5g
19690-23-4
117 suppliers
$22.10/1g
Yield: 98%
Reaction Conditions:
with hydrogen iodide in water at 15 - 20; for 2 h;Inert atmosphere;
Steps:
17.7
Preparation of 2-amino-6-iodopurine Charge 57% Hydriodic acid (10.90 kg) into a suitable vessel under nitrogen and then the solution was cooled to 0 to 10° C. Then 2-amino-6-chloropurine (0.8 kg,) was charged into the solution at about 15° C. After 2 h for the completion, water (8 kg) was slowly charged to the reaction mixture at r.t. and stirred for about 0.5 h. The yellow precipitate was filtered and washed with water. The wet cake was transferred to a suitable vessel, and water (2.0 kg) and 20% NaOH aqueous solution (0.4 kg) were slowly charged to dissolve the solids at r.t. Then THF (2.14 kg) was charged into the solution and 10% HOAc (4.8 kg) was slowly charged into the solution at about 35° C. to observe slurry mixture. The resultant slurry was stirred filtered and washed with acetone (3.8). The wet cake was dried under vacuum at 70° C. to afford SPT1255C1 (1.14 kg). Yield: 90-98%. 1H NMR (400 MHz, DMSO-d6) 6.65 (s, 2H, NH2), 8.04 (s, 1H, H8)
References:
ScinoPharm Taiwan, Ltd. US2011/201809, 2011, A1 Location in patent:Page/Page column 16
7440-44-0
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$12.00/25g
10310-21-1
535 suppliers
$10.00/5g
19690-23-4
117 suppliers
$22.10/1g
10310-21-1
535 suppliers
$10.00/5g
19690-23-4
117 suppliers
$22.10/1g