2-AMINO-6-METHOXY-NICOTINIC ACID synthesis

7synthesis methods

Product Name:2-AMINO-6-METHOXY-NICOTINIC ACID
CAS Number:1196156-84-9
Molecular formula:C7H8N2O3
Molecular Weight:168.15

67-56-1 Synthesis

67-56-1
736 suppliers
$9.00/25ml

124-41-4 Synthesis

124-41-4
681 suppliers
$12.00/25g

58584-92-2 Synthesis

2-Amino-5-chloropyridine-3-carboxylic acid

58584-92-2
145 suppliers
$18.00/250mg

1196156-84-9
33 suppliers
inquiry

Yield:1196156-84-9 156 mg

Reaction Conditions:

for 336 h;Reflux;

Steps:

69.1 Step 1: 2-Amino-6-methoxynicotinic acid

To a solution of 2-amino-6-chloronicotinic acid (900 mg, 5.4 mmol) in 25 mL methanol was added sodium methoxide (2.81 g, 52.2 mmol). The resulting mixture was stirred at reflux for two weeks. After cooled to room temperature, the solvent was removed in vacuo and the residue was purified by C18 reverse phase column [Mobile Phase A: Water, Mobile Phase B: Acetonitrile; Gradient: 0% B to 60% B in 25 min] to give 156 mg of the title compound as a white solid. MS (ESIpos): m/z = 169 (M+H)⁺; LC-MS [Method 2]: R, = 0.66 min.

References:

WO2019/170543,2019,A1 Location in patent:Page/Page column 105-106

1227048-93-2 Synthesis