2-AMINO-N-FURAN-2-YLMETHYL-BENZAMIDE synthesis

5synthesis methods

Product Name:2-AMINO-N-FURAN-2-YLMETHYL-BENZAMIDE
CAS Number:117507-63-8
Molecular formula:C12H12N2O2
Molecular Weight:216.24

617-89-0 Synthesis

617-89-0
263 suppliers
$16.00/25g

134-20-3 Synthesis

134-20-3
580 suppliers
$16.00/25mL

117507-63-8
31 suppliers
$45.00/100mg

Yield:117507-63-8 94%

Reaction Conditions:

with trimethylaluminum in toluene at 20 - 100; for 5 h;

Steps:

32

Example 32 [0307] methyl 2-aminobenzoate (0.857 mL, 6.62 mmol) and furan-2-ylmethanamine (1.84 mL, 19.9 mmol) in toluene (20.0 mL) was treated at room temperature with AlMe₃(6.62 mL, 2.0 M in toluene, 13.2 mmol). The reaction mixture was stirred at 100° C. for 5 h and then quenched with water after cooling to room temperature. The reaction mixture was concentrated in vacuo and the crude residue was purified via silica gel chromatography using a gradient of 0-80% of EtOAc in hexanes to give 1.35 g (94%) of the title compound as a white solid. LC-MS Retention Time: t₁(Method 1)=3.644 min.

References:

US2015/119426,2015,A1 Location in patent:Paragraph 0307-0308

118-48-9 Synthesis