2-benzyl-5-methoxyphthalimide synthesis
- Product Name:2-benzyl-5-methoxyphthalimide
- CAS Number:1007455-12-0
- Molecular formula:C16H13NO3
- Molecular Weight:267.28
3997-85-1
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Yield:1007455-12-0 96%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 19 - 24;
Steps:
2-Benzyl-5-methoxy-isoindole-1 ,3-dione lodomethane (168.51 g, 73.9 ml_, 1.187 mol, 1.5 equiv) was added slowly to stirred suspension of 2-Benzyl-5-hydroxy-isoindole-1 ,3-dione (200.2 g, 0.791 mol, 1.0 equiv) and K2CO3 (163.81 g, 1.187 mol, 1.5 equiv) in DMF (2.5 L). The reaction mixture warmed from 19 to 24 0C during the addition. The yellow suspension was stirred at room temperature overnight. The reaction mixture was poured into H2O (7 L). The resulting white solid was collected, washed with H2O (4 x 1 L), dried on the filter under a stream of N2 for 2 h, then in a vacuum oven at -55-60 0C for 2 h to give 202.02 g (96%) of 2-Benzyl-5-methoxy-isoindole- 1 ,3-dione. MS: APCI: M+: 267.0 (267.1 ).
References:
WO2008/20306,2008,A2 Location in patent:Page/Page column 22-23
28281-76-7
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1007455-12-0
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1007455-12-0
12 suppliers
$45.00/10mg