2-BROMO-1-(3,5-DIMETHOXYPHENYL)ETHANONE synthesis

5synthesis methods

Product Name:2-BROMO-1-(3,5-DIMETHOXYPHENYL)ETHANONE
CAS Number:50841-50-4
Molecular formula:C10H11BrO3
Molecular Weight:259.1

39151-19-4
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50841-50-4
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Yield:50841-50-4 90%

Reaction Conditions:

with tetra-N-butylammonium tribromide in tetrahydrofuran;methanol at 20; for 2 h;Solvent;Concentration;

Steps:

1.1; 2

(1) 100g of 3,5-dimethoxyacetophenone (MW: 180.20, 0.55mol)Add 300mL tetrahydrofuran and 100mL methanol into a three-necked flask,Add 294g (MW: 482.18, 0.61mol) tetrabutylammonium tribromide,The reaction was stirred at room temperature for 2h. After the reaction,Add 1L isopropanol and 1L purified water to the system,Stir and crystallize in an ice-water bath for 2h, filter under reduced pressure,The filter cake was air-dried at 50°C for 8 hours to obtain 129g of light yellow solid(90% molar yield).

References:

CN112209841,2021,A Location in patent:Paragraph 0054-0056; 0061-0074

39151-19-4
190 suppliers
$17.00/250mg

7440-44-0 Synthesis