2-Bromo-1-bromomethyl-5-chlorobenzene synthesis
- Product Name:2-Bromo-1-bromomethyl-5-chlorobenzene
- CAS Number:66192-24-3
- Molecular formula:C7H5Br2Cl
- Molecular Weight:284.38
14495-51-3
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66192-24-3
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Yield:66192-24-3 80%
Reaction Conditions:
with NBS;(E)-2,2'-(diazene-1,2-diyl)bis( 2-methylpropanenitrile) in Carbon tetrachloride; for 2 h;Heating / reflux;
Steps:
2.1
20.5 g (100 mmol) of 2-bromo-5-chlorotoluene was dissolved in 200 ml of carbon tetrachloride, 0.2 g (1 mmol) of AIBN and 19.6 g (110 mmol) of N-bromosuccinimide were added thereto, the resulting mixture was refluxed for 2 hours and cooled to room temperature. The reaction mixture was washed with 50 ml of water twice and with 50 ml of a brine solution, dried over anhydrous MgS04, and distilled under a reduced pressure to obtain an oil containing a small amount of the starting material. The oil was dissolved in 20 ml of hexane, and recrystallized at room temperature to obtain ' 22.7 g (yield 80%) of 2-bromo-l-bromomethyl-5-chlorobenzene. 1H NMR (300 MHz, CDC13) d 7.50 (d, 1H, J= 8.7 Hz), 7.45 (d, 1H, J= 2.4 Hz), 7.15 (dd, 1H, J= 8.7 Hz, 2.4 Hz), 4.53 (s, 2H)
References:
WO2005/123054,2005,A1 Location in patent:Page/Page column 25
19398-61-9
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$10.00/5G
66192-24-3
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$9.00/1g
108-41-8
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66192-24-3
118 suppliers
$9.00/1g