2-BROMO-3,4-DIFLUOROANISOLE synthesis

Yield:-

Steps:

Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 0.17 h / 150 °C / Microwave irradiation
2: 10 wt% Pd(OH)2 on carbon; hydrogen / ethanol / 80 °C
3: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C

References:

Andres, Jose-Ignacio;Alcazar, Jesus;Cid, Jose Maria;De Angelis, Meri;Iturrino, Laura;Trabanco, Andres A.;Langlois, Xavier;Lavreysen, Hilde;Celen, Sofie;Bormans, Guy [Journal of Medicinal Chemistry,2012,vol. 55,# 20,p. 8685 - 8699,15]