![](/CAS/GIF/446-59-3.gif)
2-Bromo-3-fluoroanisole synthesis
- Product Name:2-Bromo-3-fluoroanisole
- CAS Number:446-59-3
- Molecular formula:C7H6BrFO
- Molecular Weight:205.02
Yield: 90%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 24 h;
Steps:
1 6.1.1. Synthesis of different fluoro-substituted phenylate derivatives
General procedure: To a solution of 2-bromo-4-fluorophenol (0.1 mol) in DMF (100 ml) was added K2CO3 (0.1 mol) and ethyl iodide (methyl iodide or propyl iodide) (0.1 mol) stirred 24 h at room temperature. Water (400 ml) was added and the mixture was extracted with hexane. The organic phase was washed with water, dried, filtered over a plug of silica gel and evaporated to yield the objected compound.
References:
Zhang, Heng;Xu, Xiangqing;Chen, Yin;Qiu, Yinli;Liu, Xin;Liu, Bi-Feng;Zhang, Guisen [European Journal of Medicinal Chemistry,2015,vol. 89,p. 524 - 539]
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