2-BROMO-3-NITRO-5-METHYL PYRIDINE synthesis
- Product Name:2-BROMO-3-NITRO-5-METHYL PYRIDINE
- CAS Number:23056-46-4
- Molecular formula:C6H5BrN2O2
- Molecular Weight:217.02
7464-14-4
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23056-46-4
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Yield: 86%
Reaction Conditions:
with phosphorus(V) oxybromide in N,N-dimethyl-formamide at 0 - 80; for 12 h;
Steps:
[00257] POBr3 (222.8 g, 0.78 mol) was added in portions to 2-hydroxy-5- methyl-3-nitropyridine (100 g, 0.65 mol) in DMF (500 mL) with stirring at 0-10 °C then the reaction mixture was stirred at 80 0C under nitrogen for 12 hours. Reaction mixture was cooled and poured into crushed ice (1 Kg), obtained solid was filtered, washed thoroughly with ice-cold water (2 x 500 mL), dried in a desiccator under high vacuum for one day to obtain 2-bromo-5-methyl-3- nitropyridine as yellow solid (121 g) in 86% yield. (M+H) Expected: 217; found 216.9.
References:
Location in patent:Page/Page column 52
7598-26-7
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23056-46-4
147 suppliers
$9.00/1g