2-bromo-4,4'-dichlorobutyrophenone synthesis

Yield:-

Reaction Conditions:

with bromine in dichloromethane;Petroleum ether;

Steps:

II.4 Preparation of starting materials of the formula (VIII) STR214

A solution of 358 g of bromine in 350 ml of methylene chloride is added dropwise to a solution of 483 g (2.23 mols) of 4-chlorophenyl 3-chloropropyl ketone in 1200 ml of methylene chloride at 20° C. Stirring is continued for one hour and the mixture is then evaporated down in vacuo. 300 ml of petroleum ether are added to the residue, and stirring is continued until crystallization is complete. The mixture is cooled to 10° C., and the precipitate is filtered off under suction. 582 g (88.3% of theory) of 4-chlorophenyl 1-bromo-3-chloropropyl ketone of melting point 73° C. are obtained.

References:

US4921528,1990,A