ChemicalBook CAS DataBase List 2-Bromo-5-chlorobenzaldehyde

2-Bromo-5-chlorobenzaldehyde synthesis

10synthesis methods

Product Name:2-Bromo-5-chlorobenzaldehyde
CAS Number:174265-12-4
Molecular formula:C7H4BrClO
Molecular Weight:219.46

66192-24-3 Synthesis

66192-24-3
119 suppliers
$9.00/1g

174265-12-4
223 suppliers
$6.00/1g

Yield:174265-12-4 92%

Reaction Conditions:

with 4-methylmorpholine N-oxide in acetonitrile at 0; for 2 h;Molecular sieve;

Steps:

8.2

Step 2: 2-bromo-5-chlorobenzaldehyde; 2-bromo-5-chlorobenzaldehyde was prepared according to literature precedent (/. Am. Chem. Soc. 2002, 124 (7), 1354): a mixture of activated powdered 4A molecular sieves (800 mg/mmol substrate), N- methylmorpholine-N-oxide (2 eq) and 2-bromomethyl-5-chlorobenzaldehyde (1 eq) in MeCN (0.16 M) was stirred at 0 ⁰C for 2 h. The reaction was then filtered through a pad of celite and concentrated in vacuo to afford the title compound (92 %)

References:

WO2006/46030,2006,A2 Location in patent:Page/Page column 28

587-04-2 Synthesis