2-BROMO-5-HYDROXYBENZALDEHYDE synthesis
- Product Name:2-BROMO-5-HYDROXYBENZALDEHYDE
- CAS Number:2973-80-0
- Molecular formula:C7H5BrO2
- Molecular Weight:201.02
7507-86-0
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$7.00/1g
2973-80-0
363 suppliers
$6.00/1g
Yield:2973-80-0 90.9%
Reaction Conditions:
with boron tribromide in dichloromethane at 0 - 25; for 3 h;
Steps:
343B.1
To a mixture of 2-bromo-5-methoxybenzaldehyde (2000.0 mg, 9.3 mmol) indichioromethane (10 mL) was added boron tribromide (2M in DCM; 4.65 mL, 9.3 mmol) slowly at 0 °C. The reaction was warmed up to 25 °C and stirred for 3 h. The reaction was quenched with water (10 mL) at 0°C and extracted with EtOAc (50 mL). The organic layer was washed with water (50 mL x 2) and brine (50 mL), dried over Mg504 and concentrated. The residue was purified by flash column chromatography (petroleum ether) to afford 2-bromo-5-hydroxybenzaldehyde (1.7 g, 90.9% yield) as a colorless oil.
References:
WO2017/84630,2017,A1 Location in patent:Paragraph 00976
100-83-4
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$5.00/10g
2973-80-0
363 suppliers
$6.00/1g
14472-14-1
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$10.00/5g
2973-80-0
363 suppliers
$6.00/1g
100-83-4
622 suppliers
$5.00/10g
2973-80-0
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$6.00/1g
3111-51-1
55 suppliers
$55.00/25mg
20035-32-9
88 suppliers
$57.00/250mg
100-83-4
622 suppliers
$5.00/10g
2973-80-0
363 suppliers
$6.00/1g
20035-32-9
88 suppliers
$57.00/250mg