ChemicalBook CAS DataBase List 4-BROMO-3-HYDROXYBENZALDEHYDE

4-BROMO-3-HYDROXYBENZALDEHYDE synthesis

7synthesis methods

Product Name:4-BROMO-3-HYDROXYBENZALDEHYDE
CAS Number:20035-32-9
Molecular formula:C7H5BrO2
Molecular Weight:201.02

100-83-4
619 suppliers
$5.00/10g

20035-32-9
88 suppliers
$57.00/250mg

Yield:20035-32-9 35.5 g

Reaction Conditions:

with bromine in dichloromethane;water at 0;Inert atmosphere;Solvent;

Steps:

1.4; 2.4; 3.4

Reaction step: 35.4 g of 3-hydroxybenzaldehyde and 212 ml of dichloromethane were added to a clean reaction vessel, and the mixture was replaced with vacuum nitrogen three times, stirred and cooled to below 0 ° C, 35.4 g of liquid bromine was added dropwise, and 250 ml of water was added after completion of the reaction. Adjust the pH to neutral with liquid alkali, filter by cooling, add 354ml of wet product toluene to dissolve, separate the water layer, warm the organic phase to reflux, filter by temperature, and dry to obtain 4-bromo-3-hydroxy-benzaldehyde 35.5. g.

References:

CN109053443,2018,A Location in patent:Paragraph 0025; 0034; 0051-0054; 0059; 0074-0077; 0097-0100

2737-19-1 Synthesis