![](/CAS/GIF/14847-51-9.gif)
2-bromo-5-methyl-phenol synthesis
- Product Name:2-bromo-5-methyl-phenol
- CAS Number:14847-51-9
- Molecular formula:C7H7BrO
- Molecular Weight:187.03
![6-Amino-m-cresol](/CAS/GIF/2835-98-5.gif)
2835-98-5
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$8.00/5g
![2-bromo-5-methyl-phenol](/CAS/GIF/14847-51-9.gif)
14847-51-9
118 suppliers
$9.00/100mg
Yield:14847-51-9 20%
Reaction Conditions:
with hydrogen bromide;sodium nitrite;copper(I) bromide in water;ethyl acetate;
Steps:
233.A A.
A. 2-Bromo-5-methylphenol A solution of sodium nitrite (2.8 g, 41 mmol) in 5 ml water was added rapidly with stirring to an ice-cooled mixture of 6-amino-m-cresol (5.0 g, 41 mmol) and 48% hydrobromic acid (17 ml, 100 mmol). The temperature was kept below 10° C. by addition of ice chips. The diazonium salt solution was then added in portions over a period of 30 min to a boiling mixture of copper(I) bromide (6.4 g, 22 mmol) and 48% hydrobromic acid (5 ml). The resulting mixture was refluxed for an additional 30 min, then was cooled and extracted with ether (2*100 ml). The combined organic extracts were washed with water, dried over magnesium sulfate, and evaporated. The residue was chromatographed on silica gel using 98:2 hexanes/ethyl acetate to afford 233A (1.6 g, 20%) as an oil.
References:
US2002/143024,2002,A1 US6638937,2003,B2
![m-Cresol](/CAS/GIF/108-39-4.gif)
108-39-4
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$13.00/25g
![4-Bromo-3-methylphenol](/CAS/GIF/14472-14-1.gif)
14472-14-1
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$10.00/5g
![2-bromo-5-methyl-phenol](/CAS/GIF/14847-51-9.gif)
14847-51-9
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$9.00/100mg
![5-Methyl-2-nitrophenol](/CAS/GIF/700-38-9.gif)
700-38-9
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$6.00/5g
![2-bromo-5-methyl-phenol](/CAS/GIF/14847-51-9.gif)
14847-51-9
118 suppliers
$9.00/100mg
![m-Cresol](/CAS/GIF/108-39-4.gif)
108-39-4
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$13.00/25g
![4-Bromo-3-methylphenol](/CAS/GIF/14472-14-1.gif)
14472-14-1
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$10.00/5g
![2-bromo-3-methyl-phenol](/CAS/GIF/22061-78-5.gif)
22061-78-5
98 suppliers
$7.00/100mg
![2-bromo-5-methyl-phenol](/CAS/GIF/14847-51-9.gif)
14847-51-9
118 suppliers
$9.00/100mg
![2-hydroxy-4-methylbenzenesulphonic acid](/CAS/GIF/22356-80-5.gif)
22356-80-5
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![2-bromo-5-methyl-phenol](/CAS/GIF/14847-51-9.gif)
14847-51-9
118 suppliers
$9.00/100mg