ChemicalBook CAS DataBase List 2-BROMO-6-TERT-BUTYLPYRIDINE

2-BROMO-6-TERT-BUTYLPYRIDINE synthesis

5synthesis methods

Product Name:2-BROMO-6-TERT-BUTYLPYRIDINE
CAS Number:195044-14-5
Molecular formula:C9H12BrN
Molecular Weight:214.1

626-05-1 Synthesis

626-05-1
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$9.00/10g

677-22-5
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$45.00/10ml

195044-14-5
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$45.00/10mg

Yield: 77%

Reaction Conditions:

with copper(l) iodide in tetrahydrofuran at 0 - 25; for 1 h;Inert atmosphere;

Steps:

1 Step 1 - 2-Bromo-6-tert-butyl-pyridine
To a solution of 2,6-dibromopyridine (3.00 g, 12.6 mmol, CAS 626-05-1) in THF (30 mL) was added CuI (120 mg, 633umol) followed by addition of tert-butyl(chloro)magnesium (1.7 M, 35.7 mL, CAS 677-22-5) at 0 °C. The reaction mixture was stirred at 25 °C for 1 hr. On completion, the mixture was quenched by NH4Cl aqueous (100 mL), then extracted with EA (3 X 100 mL). The organic phase was separated and washed with water (100 mL), dried over Na₂SO₄ and filtered. The filtrate was concentrated in vacuo to give the title compound (2.1 g, 77% yield) as yellow oil.¹H NMR (400 MHz, DMSO-d6) d 7.73 -7.64 (m, 1H), 7.50 -7.41 (m, 2H), 1.29 (s, 9H).

References:

KYMERA THERAPEUTICS, INC.;MAINOLFI, Nello;JI, Nan;WEISS, Matthew M.;ZHENG, Xiaozhang;ZHANG, Yi;FLEMING, Paul R. WO2020/264499, 2020, A1 Location in patent:Paragraph 00920; 001832-001834

626-05-1 Synthesis

626-05-1
507 suppliers
$9.00/10g