ChemicalBook CAS DataBase List 2-Bromobenzyl bromide

2-Bromobenzyl bromide synthesis

11synthesis methods

Product Name:2-Bromobenzyl bromide
CAS Number:3433-80-5
Molecular formula:C7H6Br2
Molecular Weight:249.93

108-88-3
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$21.80/5 mL

3433-80-5
306 suppliers
$10.00/1g

Yield:3433-80-5 24 g

Reaction Conditions:

with bromine;iron;acetic acid at 40; for 0.1 h;Irradiation;

Steps:

4 Example 4
In the reaction flask,15g of toluene was added to 100mL of glacial acetic acid,Then added to locate the catalyst iron powder 3g,Bromine was slowly added dropwise at room temperature 8mL,About 30min dropping finished,Heated to 40 after reaction 5h,Then add 300W tungsten lamp under light reaction 5h,TLC monitoring raw material reaction is complete,Solvent glacial acetic acid was distilled off under vacuum,Concentrate by adding a certain amount of 20% concentration of sodium hydroxide solution,The reaction mixture was filtered and the filtrate was extracted three times with dichloromethane. The organic phases were combined and the organic phase was dried over anhydrous sodium sulfate and concentrated to give 24 g of o-bromobenzyl bromide.

References:

Mao Along CN106986880, 2017, A Location in patent:Paragraph 0023; 0032; 0033

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