ChemicalBook CAS DataBase List 2-Bromophenol

2-Bromophenol synthesis

13synthesis methods

Product Name:2-Bromophenol
CAS Number:95-56-7
Molecular formula:C6H5BrO
Molecular Weight:173.01

To a stirred solution of appropriate organoboronic acids (0.5 mmol, 1.0 equiv.) and Et₃N(1.0 mmol, 2.0 equiv.) in CH₃CN(acetonitrile: 3 mL, H2O: 11μL, 0.6mmol, 1.2 equiv.), DAIB (0.75 mmol, 1.5 equiv.),dissolved in acetonitrile (2mL) was added drop wise at room temperature and the mixture was allowed to stir for 10 minutes at that temperature. After completion of the reaction indicated by TLC, the reaction mixture was washed with distilled water (3×7 mL) and extracted with CH₂Cl₂(3×10 mL). The combined organic phase was dried over Na₂SO₄ and after evaporating the solvent, the residue was purified by column chromatography over silica gel using hexane/EtOAc as eluent to provide the pure target product 2-Bromophenol.
Synthesis of 2-Bromophenol

244205-40-1 Synthesis

244205-40-1
319 suppliers
$9.00/1g

95-56-7
296 suppliers
$9.00/5 g

Yield:95-56-7 90%

Reaction Conditions:

with [bis(acetoxy)iodo]benzene;water;triethylamine in acetonitrile at 20; for 0.166667 h;

Steps:

General procedure for syntheses of aromatic alcohols
General procedure: To a stirred solution of appropriate organoboronic acids (0.5 mmol, 1.0 equiv.) and Et₃N(1.0 mmol, 2.0 equiv.) in CH₃CN(acetonitrile: 3 mL, H₂O: 11µL, 0.6mmol, 1.2 equiv.), DAIB (0.75 mmol, 1.5 equiv.), dissolved in acetonitrile (2mL) was added drop wise at room temperature and the mixture was allowed to stir for 10 minutes at that temperature. After completion of the reaction indicated by TLC, the reaction mixture was washed with distilled water (3×7 mL) and extracted with CH₂Cl₂(3×10 mL). The combined organic phase was dried over Na₂SO₄ and after evaporating the solvent, the residue was purified by column chromatography over silica gel using hexane/EtOAc as eluent to provide the pure target product.

References:

Chatterjee, Nachiketa;Chowdhury, Hrishikesh;Sneh, Kumar;Goswami, Avijit [Tetrahedron Letters,2014,vol. 56,# 1,p. 172 - 174] Location in patent:supporting information

FullText

60333-75-7 Synthesis

60333-75-7
12 suppliers
$444.00/1g

95-56-7
296 suppliers
$9.00/5 g

References

87280-00-0
9 suppliers
inquiry

95-56-7
296 suppliers
$9.00/5 g

References

108-86-1 Synthesis

108-86-1
497 suppliers
$10.00/5g

106-41-2
480 suppliers
$13.00/5g

95-56-7
296 suppliers
$9.00/5 g

References

269409-70-3 Synthesis

4-Hydroxyphenylboronic acid pinacol ester

269409-70-3
241 suppliers
$11.00/1g

95-56-7
296 suppliers
$9.00/5 g

References

2-Bromophenol Related Search:

2,4-Dichlorophenol 4-Aminophenol 2-Aminophenol 2-Phenylphenol 2-Iodophenol Guaiacol 2,4-DIBROMOANISOLE 2-Bromo-4-methylphenol 2,6-Dibromophenol 4,4'-Sulphonylbis(2,6-dibromophenol)