![](/CAS/GIF/186828-50-2.gif)
2-(Bromodifluoromethyl)-1,3-benzoxazole synthesis
- Product Name:2-(Bromodifluoromethyl)-1,3-benzoxazole
- CAS Number:186828-50-2
- Molecular formula:C8H4BrF2NO
- Molecular Weight:248.02
![BROMODIFLUOROACETIC ACID](/CAS/GIF/354-08-5.gif)
354-08-5
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$12.00/1 g
![2-Aminophenol](/CAS/GIF/95-55-6.gif)
95-55-6
529 suppliers
$5.00/5 g
![2-(Bromodifluoromethyl)-1,3-benzoxazole](/CAS/GIF/186828-50-2.gif)
186828-50-2
20 suppliers
$55.00/1g
Yield: 85%
Reaction Conditions:
Stage #1:bromodifluoroacetic acid with carbon tetrabromide;triethylamine;triphenylphosphine in toluene at 0; for 0.166667 h;Inert atmosphere;
Stage #2:2-amino-phenol in toluene for 8 h;Inert atmosphere;Reflux;
Steps:
4.2. General procedure for preparation of 2-bromodifluoromethyl benzo-1,3-diazoles (2)
General procedure: A 200-ml three-necked flask equipped with a condenser was charged with Ph3P (2.20 g, 8.4 mmol), Et3N (0.85 g, 8.4 mmol), CBr4 (16.8 g, 8.4 mmol), and bromodifluoro acetic acid (2.8 mmol) in toluene (10.0 ml) at 0 °C under nitrogen atmosphere. After the solution was stirred for about 10 min (ice water bath), 2-amino phenol (3.3 mmol) dissolved in toluene (5.0 ml) was added dropwise. The mixture was refluxed under stirring for 6-24 h. Solvent was evaporated under reduced pressure, and the residue was diluted with petroleum ether (60-90 °C) and filtered. The residual solid of Ph3PO and Et3N·HCl was washed with petroleum ether 3 times. The filtrate was concentrated; the residue was then purified by column chromatography to obtain the product 2.
References:
Jiang, Haizhen;Yuan, Shijie;Cai, Yeshan;Wan, Wen;Zhu, Shizheng;Hao, Jian [Journal of Fluorine Chemistry,2012,vol. 133,p. 167 - 170] Location in patent:experimental part
![2-Aminophenol](/CAS/GIF/95-55-6.gif)
95-55-6
529 suppliers
$5.00/5 g
![2-(Bromodifluoromethyl)-1,3-benzoxazole](/CAS/GIF/186828-50-2.gif)
186828-50-2
20 suppliers
$55.00/1g