2-Bromoethyl-3,4-dichlorophenyl ether synthesis

Yield:3245-41-8 85%

Reaction Conditions:

with 1-n-butyl-3-methylimidazolim bromide;sodium hydroxide at 100; for 9 h;Autoclave;

Steps:

1.1 Synthesis of 1, 2- (2-bromoethoxy) -3,4-dichlorobenzene

In a 1-liter autoclave, 106.0 g of 3,4-dichlorophenol,440g of 1,2-dibromoethane,1-butyl-3-methylimidazole bromide1.5g,The mass percentage content is 260 g of a 30% sodium hydroxide solution.Set the heating temperature to 100 ° C.The reaction continued for 9h. Cool down to room temperature,The material liquid is transferred into a separating funnel, and the mixture is left to stand for stratification.Collecting organic layers,Add a small amount of dilute lye and stir well,After standing and separating, the organic layer was subjected to rotary evaporation to recover 320 g of 1,2-dibromoethane.149 g of intermediate 2- (2-bromoethoxy) -3,4-dichlorobenzene was collected by distillation under reduced pressure. The yield was 85%.

References:

CN110642777,2020,A Location in patent:Paragraph 0023-0025